Our research program pioneers innovative studies to advance the understanding and treatment of cardiac arrhythmias. Explore our 15 active studies across four areas of focus.
Area of Focus
Local PI: Dr. Allan Skanes
A randomized controlled trial testing whether aggressive risk-factor modification combined with catheter ablation outperforms ablation alone for people with atrial fibrillationn
87 of 100 participants enrolled
Local PI: Dr. Allan Skanes
An observational companion to RASTA-AF that follows patients who decline the randomized trial, comparing their characteristics, quality of life, and outcomes.
48 of 50 participants enrolled
Local PI: Dr. Allan Skanes
Evaluates whether closing the left atrial appendage with the WATCHMAN FLX device, in addition to oral anticoagulants, reduces strokes and blood clots more than anticoagulants alone.
10 of 20 participants enrolled
Local PI: Dr. Allan Skanes
Assesses whether a patient-tailored ablation strategy guided by atrial scar mapping, added to pulmonary vein isolation, improves outcomes over PVI alone in persistent AF.
Local PI: Dr. Habib Khan
Compares pharmacological rate control with a Pace-and-Ablate conduction system pacing strategy for patients with permanent AF and heart failure.
21 of 80 participants enrolled
Area of Focus
Local PI: Dr. Habib Khan
Compares standard right ventricular pacing with left bundle branch pacing for patients who have heart block.
62 of 75 participants enrolled
Local PI: Dr. Habib Khan
Tests whether physiological pacing reduces mortality and heart-failure care, improves activity and quality of life, and better preserves cardiac function than standard right-sided pacing.
38 of 100 participants enrolled
Local PI: Dr. Habib Khan
Evaluates ultrasound-guided delivery of pacing leads deep into the septum to reduce attempts, improve safety, and minimize procedure time and radiation.
9 of 152 participants enrolled
Area of Focus
Local PI: Dr. Habib Khan
Tests a new diagnostic approach to distinguish Calcium Release Deficiency Syndrome (CRDS) from related conditions using the heart's response to pacing.
0 of 10 participants enrolled
Lead PI: Dr. Habib Khan
Builds a clinical registry to evaluate the risk factors and gene mutations associated with cardiovascular events in patients with left ventricular non-compaction.
68 of 2000 participants enrolled
Local PI: Dr. Habib Khan
A Canadian research database and biobank collecting healthcare information and samples from patients investigated and treated for inherited heart rhythm conditions.
1226 of 2500 participants enrolled
Local PI: Dr. Habib Khan
Gathers phenotypic, genotypic, treatment, and outcome data on a large cohort to better define the natural history of CRDS and identify prognostic and therapeutic tools.
2 of 100 participants enrolled
Local PI: Dr. Habib Khan
Establishes a registry, biobank, and imaging repository for patients with hypertrophic cardiomyopathy and carriers of related genetic variants to address knowledge gaps.
102 of 300 participants enrolled
Area of Focus
Local PI: Dr. Lorne Gula
Evaluates whether catheter ablation, compared with antiarrhythmic drug therapy, better controls death, ICD shocks, and ventricular tachycardia in patients with prior heart attack.
1 of 10 participants enrolled
Local PI: Dr. Habib Khan
Determines whether the drug tideglusib, compared with placebo, reduces the number of premature ventricular contractions in patients with arrhythmogenic cardiomyopathy.
3 of 10 participants enrolled
For questions about participating in or collaborating on a study, contact our research team.
Contact the Research Team