Risk Factors in Patients with LVNC (LVNC)
LVNC
Lead PI & Sponsor
Dr. Habib Khan
Local PI
Dr. Habib Khan
Research Staff
Megan Smith
Objective
The purpose of this study is to evaluate the risk factors and mutations associated with cardiovascular events in patients with a confirmed diagnosis of LVNC who have preserved cardiac function. This enhanced understanding of LVNC will result in optimized clinical care of patients and their family members.
Target Number of Patients
2000
Currently Enrolled
35
Primary Outcomes
- To develop a large clinical registry linked with the Inherited Arrhythmia Clinic and create a database associated with REDCap.
- To evaluate patients who have already achieved events such as sudden cardiac arrest (SCA) and have an implantable cardioverter defibrillator (ICD) and identify predictors for SCA through retrospective review 15 years into the past, followed by a prospective approach for new patients diagnosed with left ventricular non-compaction (LVNC).
- To evaluate disease progression in patients with genetic mutations and examine their risk of cardiac arrhythmias using provocation testing which includes stress tests and evaluate their burden of arrhythmias using Holter monitors.
Inclusion Criteria
- Meets diagnostic criteria for left-ventricular non compaction based on echocardiogram or MRI
- Patients over the age of 18
- For retrospective patients, a diagnosis between 2010-2020
Exclusion Criteria
- Genetic mutations causing other cardiomyopathies
- Unable to provide consent
The study aims to evaluate patients diagnosed with life-threatening cardiac rhythm or admission with heart failure who have left ventricular non-compaction seen on echocardiogram or cardiac MRI. The study intends to evaluate the diagnostic criteria of LV non-compaction using echo or cardiac MRI and correlating it to the type of genetic mutation, left ventricular function and burden of arrhythmia over a period of 10 years.