Objective
The purpose of this study is to evaluate the risk factors and mutations associated with cardiovascular events in patients with a confirmed diagnosis of LVNC who have preserved cardiac function. This enhanced understanding of LVNC will result in optimized clinical care of patients and their family members.
Background
The study aims to evaluate patients diagnosed with a life-threatening cardiac rhythm or admitted with heart failure who have left ventricular non-compaction seen on echocardiogram or cardiac MRI. The study intends to evaluate the diagnostic criteria of LV non-compaction using echo or cardiac MRI and correlate it to the type of genetic mutation, left ventricular function, and burden of arrhythmia over a period of 10 years.
Study Outcomes
Primary
- Develop a large clinical registry linked with the Inherited Arrhythmia Clinic and a database associated with REDCap
- Evaluate patients who have experienced events such as sudden cardiac arrest (SCA) and have an ICD, identifying predictors for SCA through retrospective review 15 years into the past, followed by a prospective approach for newly diagnosed LVNC patients
- Evaluate disease progression in patients with genetic mutations and assess their risk of cardiac arrhythmias using provocation testing (stress tests) and arrhythmia burden using Holter monitors
Secondary
Eligibility Criteria
The criteria below are a summary. Your study doctor will confirm whether this study is right for you.
Inclusion Criteria
- Meets diagnostic criteria for left ventricular non-compaction based on echocardiogram or MRI
- Patients over the age of 18
- For retrospective patients, a diagnosis between 2010–2020
Exclusion Criteria
- Genetic mutations causing other cardiomyopathies
- Unable to provide consent
About taking part
If you are considering joining this study, please review the Letter of Information below. It explains the study in detail, including what participation involves, the potential risks and benefits, and your rights as a participant.
LVNC Letter of Information